{"key":"op_491_TR","page":{"url":"https://kz.bookimed.com/clinics/country=turkey/procedure=keytruda/","procedure":{"id":491,"slug":"keytruda","name":"Иммунотерапия Кейтрудой (Пембролизумаб)","name_forms":{"plural":{"status":"missing","reason":"not_collected"},"genitive":{"status":"missing","reason":"not_collected"}},"type":"therapy","grammar_number":{"status":"missing","reason":"not_collected"},"parent_id":"oncology","family_attribute":{"status":"missing","reason":"not_collected"}},"country":{"id":46,"iso":"TR","name":"Түркия"},"currency":"USD","data_date":"2026-11-14"},"pages":{"clinics_url":"https://kz.bookimed.com/clinics/country=turkey/procedure=keytruda/","cost_url":"https://kz.bookimed.com/clinics/country=turkey/procedure=keytruda/cost/","best_url":{"status":"missing","reason":"template not live"}},"price":{"from":2800,"to":7000,"avg":{"value":5000,"method":"median","source":"clinics"},"us":{"from":13500,"to":22000},"uk":{"from":7000,"to":10500},"by_technique":{"status":"missing","reason":"not_collected"},"by_city":[{"city":"Істанбұл","from":2800},{"city":"Анқара","from":3400},{"city":"Ізмір","from":3600},{"city":"Анталия","from":3800}],"per_unit":{"status":"missing","reason":"not_collected"},"factors":{"status":"missing","reason":"not_collected"},"tiers":{"status":"missing","reason":"no_offers"},"comparison":[{"country_iso":"UA","from":4500,"to":8000},{"country_iso":"FR","from":4200,"to":7000},{"country_iso":"GB","from":7000,"to":10500},{"country_iso":"US","from":13500,"to":22000},{"country_iso":"IL","from":4800,"to":6800},{"country_iso":"MX","from":3800,"to":5500},{"country_iso":"DE","from":6000,"to":8100},{"country_iso":"CA","from":6800,"to":9800},{"country_iso":"AE","from":5600,"to":8600},{"country_iso":"TH","from":8000,"to":16000},{"country_iso":"PL","from":4300,"to":5800},{"country_iso":"KR","from":4800,"to":7500},{"country_iso":"CZ","from":3600,"to":5300},{"country_iso":"AT","from":5800,"to":8400},{"country_iso":"ES","from":13600,"to":{"status":"missing","reason":"not_collected"}},{"country_iso":"IT","from":4300,"to":6700},{"country_iso":"CN","from":4500,"to":7200},{"country_iso":"AU","from":4800,"to":7400},{"country_iso":"IN","from":2500,"to":5200},{"country_iso":"MY","from":3800,"to":5400},{"country_iso":"VN","from":4300,"to":6200},{"country_iso":"BR","from":4500,"to":7000},{"country_iso":"EG","from":1500,"to":6300}],"base_country":"US","base_is_fallback":false},"savings":{"pct":79,"variant":">=15%"},"package":{"included":{"status":"missing","reason":"no_offers"},"excluded":{"status":"missing","reason":"no_offers"},"extra_charges":{"status":"missing","reason":"not_collected"}},"clinics":{"count":29,"items":[{"id":87,"name":"Anadolu Medical Center","city":"Istanbul","rating":4.6,"reviews_count":544,"accreditations":["Planetree's Gold Certificate","International Accreditation System for Interventional Oncology Services (IASIOS)","Patient choice in Oncology & Hematology Oncology","Patient Choice for Basic Check-up","Johns Hopkins Medicine","Organisation of European Cancer Institutes Certificate","European Society for Medical Oncology","Joint Commission International","International Organization for Standardization","World's Best Hospitals 2026 by Newsweek"],"rank":1,"has_procedure":true,"why_ranked":"Uses Keytruda (pembrolizumab) for targeted immunotherapy. Partnered with Johns Hopkins Hospital, JCI accredited, and offers comprehensive oncology services with advanced diagnostic tools.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":96,"name":"Memorial Şişli Hospital","city":"Istanbul","rating":4.6,"reviews_count":437,"accreditations":["International Organization for Standardization","Joint Commission International"],"rank":2,"has_procedure":true,"why_ranked":"JCI-accredited clinic with a 90% organ transplant success rate. Specializes in oncology and offers personalized treatment plans under experienced oncologists.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":2943,"name":"Istanbul Florence Nightingale Hospital","city":"Istanbul","rating":5,"reviews_count":58,"accreditations":["Joint Commission International","International Organization for Standardization"],"rank":3,"has_procedure":true,"why_ranked":"JCI-accredited hospital with specialized oncologists. Offers Keytruda immunotherapy combined with chemotherapy, administered every three weeks. Doctors have led clinical trials in targeted therapies.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":426,"name":"Hisar Hospital Intercontinental","city":"Istanbul","rating":4.5,"reviews_count":266,"accreditations":["Joint Commission International","Turkish Medical Association (Türk Tabıplerı Bırliği)","Turkish Medical Association","Patient choice in Oncology & Hematology Oncology","Best patient assistance","Best clinic for radiotherapy"],"rank":4,"has_procedure":true,"why_ranked":"JCI-accredited oncology center with personalized immunotherapy programs. Offers MSI testing to determine Keytruda suitability, ensuring targeted treatment. Doctors have managed complex cancer cases with international training.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":3418,"name":"Valued Med Hub Hospitals","city":"Istanbul","rating":4.9,"reviews_count":59,"accreditations":["Turkish Medical Association","International Health Tourism Authorization Certificate"],"rank":5,"has_procedure":true,"why_ranked":"Specializes in personalized immunotherapy with Keytruda, offers combined therapy approaches, and has a 98% patient recommendation rate. Doctors have performed 1,100+ procedures.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":7176,"name":"Memorial Göztepe Hospital","city":"Istanbul","rating":4.8,"reviews_count":9,"accreditations":{"status":"missing","reason":"not_collected"},"rank":6,"has_procedure":true,"why_ranked":"Access to the latest global immunotherapy innovations through a dedicated Clinical Research Unit. AI-powered 3 Tesla MRI and PET/CT scans precisely monitor treatment response. Multidisciplinary tumor board personalizes each plan.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":417,"name":"Memorial Antalya Hospital","city":"Antalya","rating":4.6,"reviews_count":152,"accreditations":["Joint Commission International"],"rank":7,"has_procedure":true,"why_ranked":"Follows NCCN and ESMO protocols for oncology treatments. Offers Keytruda for eligible prostate cancer cases. JCI-accredited facility with personalized treatment plans.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":410,"name":"Memorial Bahçelievler Hospital","city":"Istanbul","rating":4.6,"reviews_count":165,"accreditations":["International Organization for Standardization","Joint Commission International"],"rank":8,"has_procedure":true,"why_ranked":"Offers immunotherapy with Keytruda, a leading treatment for advanced cancers, with personalized care plans and international patient support. 91% of clients recommend the clinic.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":432,"name":"Memorial Ataşehir Hospital","city":"Istanbul","rating":4.5,"reviews_count":55,"accreditations":["Joint Commission International"],"rank":9,"has_procedure":true,"why_ranked":"Cancer center combines medical oncology, radiation oncology and nuclear medicine under one roof. Treatment plans set by Memorial Oncology Councils with input from all departments. JCI-accredited.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1248,"name":"Lokman Hekim Istanbul Hospital","city":"Istanbul","rating":4.8,"reviews_count":303,"accreditations":["Certification according to DIN EN ISO 9001 by TÜV NORD CERT","Joint Commission International"],"rank":10,"has_procedure":true,"why_ranked":"Provides comprehensive initial examinations including biopsy and radiological screenings. Clinic has a 4.6 rating based on 20 patient reviews and 94% recommendation rate. Offers interpreter services and airport transfers.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1764,"name":"Lokman Hekim University Ankara Hospital","city":"Ankara","rating":4.8,"reviews_count":10,"accreditations":["International Health Tourism Authorization Certificate","International Organization for Standardization"],"rank":11,"has_procedure":true,"why_ranked":"Diagnostic package includes PET-CT alongside Keytruda (pembrolizumab) therapy. Medical oncologist trained at Hacettepe University Oncology Institute. ISO-certified hospital with 98% patient recommendation.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":5614,"name":"VM Medical Park Pendik Hospital","city":"Istanbul","rating":3,"reviews_count":2,"accreditations":["Joint Commission International"],"rank":12,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":5615,"name":"Medical Park Antalya Hospital Complex","city":"Antalya","rating":4.4,"reviews_count":8,"accreditations":["International Health Tourism Authorization Certificate"],"rank":13,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":276,"name":"Neolife Medical Center","city":"Istanbul","rating":4.7,"reviews_count":19,"accreditations":["International Organization for Standardization","Joint Commission International"],"rank":14,"has_procedure":true,"why_ranked":"JCI-accredited oncology center where immunotherapy plans use molecular diagnostics with PET/CT, MRI and CT, and complex cases go to a Multidisciplinary Tumor Board. 90,000+ patients treated.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":765,"name":"Istinye University Liv Hospital Bahcesehir","city":"Istanbul","rating":4.2,"reviews_count":19,"accreditations":["Best clinic for radiotherapy","Best price for PET/CT","Turkish Medical Association"],"rank":15,"has_procedure":true,"why_ranked":"Specializes in immunotherapy with Keytruda, administered every 21 days. Offers double immunotherapy for complex cases. Doctors have extensive experience in medical oncology.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":2778,"name":"Lokman Hekim Akay Hospital","city":"Ankara","rating":5,"reviews_count":2,"accreditations":{"status":"missing","reason":"not_collected"},"rank":16,"has_procedure":true,"why_ranked":"Tumor gene mapping identifies targeted drugs beyond Keytruda for lung cancer. Clinic recommends switching to Durvalumab plus Tremelimumab based on molecular profiling.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":85,"name":"Medipol Mega University Hospital","city":"Istanbul","rating":4.5,"reviews_count":495,"accreditations":["Joint Commission International","Patient choice in Pediatric Oncology & Hematology Oncology"],"rank":17,"has_procedure":true,"why_ranked":"JCI accredited with specialized oncology hospital. Offers Keytruda immunotherapy and comprehensive diagnostic services with PET-CT and pathology reviews.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1173,"name":"Emsey Hospital","city":"Istanbul","rating":4.1,"reviews_count":42,"accreditations":["The Baby-friendly Hospital Initiative (BFHI) by WHO and UNICEF","Turkish Medical Association","TEMOS International Healthcare Accreditation","Certification according to DIN EN ISO 9001 by TÜV NORD CERT","International Health Tourism Authorization Certificate","International Organization for Standardization"],"rank":18,"has_procedure":true,"why_ranked":"Offers comprehensive immunotherapy packages with genetic testing to tailor treatment. JCI-accredited facility with dedicated oncology department and 20+ years of specialist experience.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1547,"name":"Estophia Hospital","city":"Istanbul","rating":4.4,"reviews_count":49,"accreditations":{"status":"missing","reason":"not_collected"},"rank":19,"has_procedure":true,"why_ranked":"Offers comprehensive immunotherapy sessions with pre-treatment tests and oncologist consultations. Provides airport-clinic transfers and daily room for patients during treatment.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1169,"name":"Hermes Clinics (Hermes Clinics A.Ş.)","city":"Ankara","rating":4.5,"reviews_count":20,"accreditations":["Joint Commission International"],"rank":20,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":4904,"name":"Medipol Bahçelievler Univesity Hospital","city":"Istanbul","rating":4.5,"reviews_count":2,"accreditations":["Joint Commission International"],"rank":21,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":3887,"name":"Private Koru Ankara Hospital","city":"Ankara","rating":2,"reviews_count":1,"accreditations":["Turkish Medical Association","Joint Commission International"],"rank":22,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":397,"name":"SALUSS Medical Group","city":"Antalya","rating":4.6,"reviews_count":98,"accreditations":["Turkish Medical Association","Straumann® Dental Implant System Official Provider"],"rank":23,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1424,"name":"HayatMed Clinic","city":"Istanbul","rating":{"status":"missing","reason":"not_collected"},"reviews_count":{"status":"missing","reason":"not_collected"},"accreditations":["Joint Commission International","Turkish Medical Association","Given to the doctor International Society of Aesthetic Plastic Surgery (ISAPS) Сertificate","American Society of Plastic Surgeons","ISO 9001:2015 Quality management systems"],"rank":24,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":1602,"name":"Acibadem Altunizade Clinic","city":"Istanbul","rating":4.4,"reviews_count":7,"accreditations":["International Organization for Standardization","Joint Commission International","LEED Platinum Sertificate for ECO Buildings"],"rank":25,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":4078,"name":"Uniqacare Clinic","city":"Istanbul","rating":{"status":"missing","reason":"not_collected"},"reviews_count":{"status":"missing","reason":"not_collected"},"accreditations":["Turkish Medical Association"],"rank":26,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":4441,"name":"EKOL International HOSPITALS - İzmir","city":"İzmir","rating":{"status":"missing","reason":"not_collected"},"reviews_count":{"status":"missing","reason":"not_collected"},"accreditations":["Turkish Medical Association","International Organization for Standardization","International Health Tourism Authorization Certificate"],"rank":27,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":4464,"name":"Private Medicabil Hospital","city":"Bursa","rating":{"status":"missing","reason":"not_collected"},"reviews_count":{"status":"missing","reason":"not_collected"},"accreditations":["International Organization for Standardization","International Health Tourism Authorization Certificate","Joint Commission International"],"rank":28,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":4960,"name":"BP Klinik","city":"Turkey","rating":{"status":"missing","reason":"not_collected"},"reviews_count":{"status":"missing","reason":"not_collected"},"accreditations":["Turkish Medical Association","International Health Tourism Authorization Certificate","Turkish Medical Association (Türk Tabıplerı Bırliği)"],"rank":29,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}}]},"doctors":{"count":30,"languages":{"status":"missing","reason":"not_collected"}},"cities":[{"id":107,"slug":"istanbul","name":"Істанбұл","clinics_count":8,"price_from":2800,"profile":{"city_type":"Largest city in Turkey, megacity","access":["Sabiha Gökçen Airport (SAW), 32 km southeast of city center"],"sources":["https://en.wikipedia.org/wiki/Istanbul","https://en.wikipedia.org/wiki/Sabiha_G%C3%B6k%C3%A7en_International_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":386,"slug":"ankara","name":"Анқара","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":3400,"profile":{"city_type":"Capital city of Turkey","access":["Ankara Airport (ESB), 28 km from the city center"],"sources":["https://en.wikipedia.org/wiki/Ankara","https://en.wikipedia.org/wiki/Ankara_Esenboğa_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":395,"slug":"izmir","name":"Ізмір","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":3600,"profile":{"city_type":"Aegean coastal port city in Turkey","access":["Izmir Airport (ADB), 14 km from the city center"],"sources":["https://en.wikipedia.org/wiki/%C4%B0zmir","https://en.wikipedia.org/wiki/Izmir_Adnan_Menderes_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":382,"slug":"antalya","name":"Анталия","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":3800,"profile":{"city_type":"Major Mediterranean coastal city in Turkey","access":["Antalya Airport (AYT), 13 km from the city center"],"sources":["https://en.wikipedia.org/wiki/Antalya","https://en.wikipedia.org/wiki/Antalya_Airport"],"checked_at":"2026-11-03","status":"ok"}}],"offers":{"active":{"status":"missing","reason":"no_offers"},"active_with_related":{"status":"missing","reason":"no_offers"},"hospital_nights_median":{"status":"missing","reason":"no_offers"},"days_in_country_median":{"status":"missing","reason":"no_offers"},"top_offers":{"status":"missing","reason":"no_offers"},"packages":{"status":"missing","reason":"no_offers"},"related_packages":{"status":"missing","reason":"no_offers"},"other_packages":{"status":"missing","reason":"no_offers"}},"medical":{"indications":["Advanced or metastatic melanoma; adjuvant melanoma after resection","Non-small cell lung cancer (alone or with chemotherapy)","Head and neck squamous cell carcinoma","Classical Hodgkin lymphoma (relapsed/refractory)","Urothelial carcinoma","MSI-high/dMMR solid tumors including colorectal cancer","Other approved cancers (cervical, endometrial, gastric, renal, breast)","Merkel cell carcinoma"],"contraindications":["Prior severe hypersensitivity to pembrolizumab or its components","Pregnancy (can harm the fetus)","Severe active autoimmune disease needing immunosuppression (relative)","Active uncontrolled infection (relative; treat first)","Prior solid organ transplant (relative; graft rejection risk)"],"operation_hours":{"min":0.5,"max":1,"unit":"hours","qualifier":"Dose (200 mg every 3 weeks or 400 mg every 6 weeks) infused over 30 minutes, plus brief observation."},"anesthesia":["none"],"sessions_or_stages":{"sessions":{"min":1,"max":35,"unit":"visits","qualifier":"Infusions every 3 or 6 weeks for up to about 2 years (35 three-weekly cycles) or until progression."},"stages":[{"code":"infusion_cycles","label":"Repeated intravenous pembrolizumab infusions every 3 or 6 weeks","after":{"min":0,"max":730,"unit":"days","qualifier":"Spans the whole course from the first infusion."}}],"qualifier":"Number of cycles depends on cancer type, regimen, response and tolerance."},"hospital_nights":{"value":{"min":0,"max":0,"unit":"nights","qualifier":"Per infusion; given as an outpatient infusion with no overnight stay."},"source":"parsed_details"},"treatment_conditions":["outpatient"],"rehabilitation_days":{"min":0,"max":2,"unit":"days","qualifier":"Outpatient infusion with no surgical recovery; usual activities resume within 0-2 days, depending on fatigue and side effects."},"fly_home_after_days":{"min":1,"max":2,"unit":"days","qualifier":"Outpatient infusion with no wound; flying is possible once no reaction occurs and you feel well."},"back_to_work_days":{"min":0,"max":2,"unit":"days","qualifier":"Most return to usual activities within 0-2 days, depending on fatigue, side effects and cancer type."},"exercise_resume_weeks":{"min":0,"max":1,"unit":"weeks","qualifier":"No procedural restriction; light activity encouraged. Strenuous exercise within about a week, limited by fatigue."},"final_result_months":{"min":3,"max":6,"unit":"months","qualifier":"Best response often seen within 3-6 months; responses may deepen later."},"result_longevity":"In responders, benefit is often durable, lasting years and sometimes continuing after the course (up to about 2 years) ends. Duration depends on cancer type, stage and biomarkers.","main_risks":["Immune-related organ inflammation (lungs, colon, liver, thyroid, kidneys, skin)","Fatigue, rash, itching, diarrhea, nausea","Infusion-related reactions","Type 1 diabetes, adrenal or pituitary insufficiency","Myocarditis (rare)","Serious or fatal immune events needing steroids and interruption"],"complication_rate_pct":{"min":10,"max":20,"unit":"percent","qualifier":"Grade 3-5 treatment-related adverse events with monotherapy in pivotal trials; higher with chemotherapy or TKIs."},"revision_rate_pct":{"status":"missing","reason":"not_collected"},"success":{"metric":"Overall survival at 5 years (advanced NSCLC, PD-L1 ≥50%)","value":31.9,"horizon":"5 years","source":{"status":"missing","reason":"not_collected"},"evidence_status":"limited"},"scars":"No scarring is expected; at most there is a tiny, temporary mark at the IV cannulation site.","pain":"Minimal; only mild discomfort from IV cannulation. Side effects such as joint or muscle pain may occur in some patients.","preparation":["Confirmed cancer and approved indication; biomarker testing if relevant","Baseline blood tests: liver, kidney, thyroid, glucose","Baseline imaging for staging","Review of autoimmune history, transplant history and current medications","Pregnancy test and contraception counseling where relevant","Discussion of side effects and when to report symptoms urgently","Hepatitis B/C and HIV screening; exclude active tuberculosis","Baseline ECOG performance status assessment","Adequate venous access for intravenous infusion"],"recovery_timeline":[{"phase":"Infusion day","description":"About 30-minute IV infusion with brief observation; most patients go home the same day.","restrictions":{"status":"missing","reason":"not_collected"}},{"phase":"First days after each infusion","description":"Possible mild fatigue, rash or flu-like symptoms. Promptly report cough, breathlessness, severe diarrhea or rash, jaundice or weakness.","restrictions":{"status":"missing","reason":"not_collected"}},{"phase":"Ongoing treatment","description":"Cycles every 3 or 6 weeks with monitoring for delayed immune-related side effects, which can appear months into treatment or after it ends.","restrictions":["Do not self-treat immune-related symptoms; contact the oncology team"]}],"follow_up_visits":[{"purpose":"assessment","requirement":"routine","after":{"min":21,"max":42,"unit":"days","qualifier":"Clinical review and blood tests before each subsequent cycle (every 3 or 6 weeks depending on regimen)."}},{"purpose":"result_review","requirement":"routine","after":{"min":42,"max":84,"unit":"days","qualifier":"First response imaging is typically about 6-12 weeks after starting treatment."}}],"sources":{"status":"missing","reason":"not_collected"},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check that the medical team treating you has suitable qualifications","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C2","text":"Check that you can ask the treating team questions about your treatment","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you been able to ask them questions about your treatment?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C3","text":"Check that you are satisfied with the facilities and standards where you will be treated","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Are you satisfied with the facilities and standards at the clinic or hospital where you'll be treated?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C4","text":"Check how your aftercare will be coordinated once treatment is over","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Ensure you're clear about how your aftercare will be coordinated.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C5","text":"Check whether follow-up care takes place at the same facility as the procedure","scope":"treatment_abroad","source":{"url":"https://www.cdc.gov/yellow-book/hcp/health-care-abroad/medical-tourism.html","host":"cdc.gov","quote":"Medical tourists should also know whether follow-up care is scheduled to occur at the same facility as the procedure.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":403}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"The clinic or hospital refuses to discuss the details of the treatment when asked","scope":"treatment_abroad","source":{"url":"https://www.rcseng.ac.uk/patient-care/cosmetic-surgery/having-surgery-abroad","host":"rcseng.ac.uk","quote":"Be wary of surgeons and hospitals that do not want to discuss the details of surgery with you.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F2","text":"An advert or information that guarantees complete success should raise concerns","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F3","text":"Forceful persuasion or cheap, time-limited offers pushing you into a quick decision","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Fevers or flu-like symptoms with a rash","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Contact your care team right away if you notice fevers or flu-like symptoms with a rash.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W2","text":"Allergic reaction to the medicine","urgency":"contact_clinic","general":false,"source":{"url":"https://www.healthline.com/health/drugs/keytruda","host":"healthline.com","quote":"Call your doctor right away if you have an allergic reaction to Keytruda.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W3","text":"Any change in eyesight","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Tell your care team right away if you have any change in your eyesight.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W4","text":"Shortness of breath or trouble breathing","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Dry cough, shortness of breath or trouble breathing.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W5","text":"Chest pain or fast or irregular heartbeat","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Heart muscle inflammation—unusual weakness or fatigue, shortness of breath, chest pain, fast or irregular heartbeat.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Gives your home doctor information about your treatment and future care needs","document":"discharge letter for gp","source":{"url":"https://www.nhs.uk/using-the-nhs/nhs-services/hospitals/being-discharged-from-hospital/","host":"nhs.uk","quote":"You'll also be given a letter for your GP, providing information about your treatment and future care needs.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"T2","text":"Ask for copies of all prescriptions before you leave","document":"prescription copies","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Remember to ask for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T3","text":"Home doctor needs the dates for required blood tests and follow-up appointments","document":"written aftercare plan","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"This should include any medication and doses, as well as any dates that blood tests and follow-up appointments must be carried out.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T4","text":"Tells any doctor the patient is on immunotherapy, so side effects are managed correctly","document":"immunotherapy wallet card","source":{"url":"https://www.ons.org/toolkits/immunotherapy-patient-wallet-card-1","host":"ons.org","quote":"The ONS Immunotherapy Patient Wallet Card is intended to communicate with healthcare providers who are not involved with a patient's cancer treatment.","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1}},"parsed_details":{"procedure_type":"therapy","fields":{"anesthesia":["none"],"back_to_work_days":{"min":0,"max":2,"unit":"days","qualifier":"Most return to usual activities within 0-2 days, depending on fatigue, side effects and cancer type."},"complication_rate_pct":{"min":10,"max":20,"unit":"percent","qualifier":"Grade 3-5 treatment-related adverse events with monotherapy in pivotal trials; higher with chemotherapy or TKIs."},"contraindications":["Prior severe hypersensitivity to pembrolizumab or its components","Pregnancy (can harm the fetus)","Severe active autoimmune disease needing immunosuppression (relative)","Active uncontrolled infection (relative; treat first)","Prior solid organ transplant (relative; graft rejection risk)"],"days_in_clinic":{"min":0,"max":0,"unit":"nights","qualifier":"Per infusion; given as an outpatient infusion with no overnight stay."},"diagnostic_duration_minutes":null,"diagnostic_preparation":null,"diagnostic_referral_needed":null,"diagnostic_result_time_hours":null,"exercise_resume_weeks":{"min":0,"max":1,"unit":"weeks","qualifier":"No procedural restriction; light activity encouraged. Strenuous exercise within about a week, limited by fatigue."},"final_result_months":{"min":3,"max":6,"unit":"months","qualifier":"Best response often seen within 3-6 months; responses may deepen later."},"fly_home_after_days":{"min":1,"max":2,"unit":"days","qualifier":"Outpatient infusion with no wound; flying is possible once no reaction occurs and you feel well."},"follow_up_visits":[{"purpose":"assessment","requirement":"routine","after":{"min":21,"max":42,"unit":"days","qualifier":"Clinical review and blood tests before each subsequent cycle (every 3 or 6 weeks depending on regimen)."}},{"purpose":"result_review","requirement":"routine","after":{"min":42,"max":84,"unit":"days","qualifier":"First response imaging is typically about 6-12 weeks after starting treatment."}}],"indications":["Advanced or metastatic melanoma; adjuvant melanoma after resection","Non-small cell lung cancer (alone or with chemotherapy)","Head and neck squamous cell carcinoma","Classical Hodgkin lymphoma (relapsed/refractory)","Urothelial carcinoma","MSI-high/dMMR solid tumors including colorectal cancer","Other approved cancers (cervical, endometrial, gastric, renal, breast)","Merkel cell carcinoma"],"main_risks":["Immune-related organ inflammation (lungs, colon, liver, thyroid, kidneys, skin)","Fatigue, rash, itching, diarrhea, nausea","Infusion-related reactions","Type 1 diabetes, adrenal or pituitary insufficiency","Myocarditis (rare)","Serious or fatal immune events needing steroids and interruption"],"pain":"Minimal; only mild discomfort from IV cannulation. Side effects such as joint or muscle pain may occur in some patients.","preparation":["Confirmed cancer and approved indication; biomarker testing if relevant","Baseline blood tests: liver, kidney, thyroid, glucose","Baseline imaging for staging","Review of autoimmune history, transplant history and current medications","Pregnancy test and contraception counseling where relevant","Discussion of side effects and when to report symptoms urgently","Hepatitis B/C and HIV screening; exclude active tuberculosis","Baseline ECOG performance status assessment","Adequate venous access for intravenous infusion"],"recovery_timeline":[{"phase":"Infusion day","description":"About 30-minute IV infusion with brief observation; most patients go home the same day.","restrictions":[]},{"phase":"First days after each infusion","description":"Possible mild fatigue, rash or flu-like symptoms. Promptly report cough, breathlessness, severe diarrhea or rash, jaundice or weakness.","restrictions":[]},{"phase":"Ongoing treatment","description":"Cycles every 3 or 6 weeks with monitoring for delayed immune-related side effects, which can appear months into treatment or after it ends.","restrictions":["Do not self-treat immune-related symptoms; contact the oncology team"]}],"rehabilitation_days":{"min":0,"max":2,"unit":"days","qualifier":"Outpatient infusion with no surgical recovery; usual activities resume within 0-2 days, depending on fatigue and side effects."},"result_longevity":"In responders, benefit is often durable, lasting years and sometimes continuing after the course (up to about 2 years) ends. Duration depends on cancer type, stage and biomarkers.","revision_rate_pct":null,"scars":"No scarring is expected; at most there is a tiny, temporary mark at the IV cannulation site.","sessions_or_stages":{"sessions":{"min":1,"max":35,"unit":"visits","qualifier":"Infusions every 3 or 6 weeks for up to about 2 years (35 three-weekly cycles) or until progression."},"stages":[{"code":"infusion_cycles","label":"Repeated intravenous pembrolizumab infusions every 3 or 6 weeks","after":{"min":0,"max":730,"unit":"days","qualifier":"Spans the whole course from the first infusion."}}],"qualifier":"Number of cycles depends on cancer type, regimen, response and tolerance."},"success":{"metric":"Overall survival at 5 years (advanced NSCLC, PD-L1 ≥50%)","value":31.9,"unit":"percent","horizon":"5 years","population":"Adults with untreated advanced NSCLC, PD-L1 ≥50%, on pembrolizumab monotherapy","evidence_status":"limited"},"techniques":[{"name":"Pembrolizumab monotherapy","suits_whom":"Patients with suitable biomarkers (e.g., high PD-L1, MSI-high) or melanoma","recovery":"Outpatient infusion; no downtime in most patients."},{"name":"Pembrolizumab combined with chemotherapy","suits_whom":"Patients such as those with non-small cell lung cancer or other tumors where the combination is approved","recovery":"Added chemotherapy side effects can increase fatigue and recovery time after each cycle."}],"treatment_conditions":["outpatient"],"treatment_duration_hours":{"min":0.5,"max":1,"unit":"hours","qualifier":"Dose (200 mg every 3 weeks or 400 mg every 6 weeks) infused over 30 minutes, plus brief observation."},"initial_assessment_documents":["Pathology report with histology","PD-L1, MSI or dMMR test results","Staging CT or PET-CT reports","Prior treatment and surgery summary","Recent blood tests with liver and thyroid function","Oncologist letter on autoimmune disease or ECOG status"],"travel_trips":{"min":2,"max":35,"one_trip_possible":false,"qualifier":"Each 3- or 6-weekly infusion needs a visit; stay 1-3 days per trip. Fewer if a local oncologist continues."},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check that the medical team treating you has suitable qualifications","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C2","text":"Check that you can ask the treating team questions about your treatment","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you been able to ask them questions about your treatment?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C3","text":"Check that you are satisfied with the facilities and standards where you will be treated","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Are you satisfied with the facilities and standards at the clinic or hospital where you'll be treated?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C4","text":"Check how your aftercare will be coordinated once treatment is over","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Ensure you're clear about how your aftercare will be coordinated.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C5","text":"Check whether follow-up care takes place at the same facility as the procedure","scope":"treatment_abroad","source":{"url":"https://www.cdc.gov/yellow-book/hcp/health-care-abroad/medical-tourism.html","host":"cdc.gov","quote":"Medical tourists should also know whether follow-up care is scheduled to occur at the same facility as the procedure.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":403}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"The clinic or hospital refuses to discuss the details of the treatment when asked","scope":"treatment_abroad","source":{"url":"https://www.rcseng.ac.uk/patient-care/cosmetic-surgery/having-surgery-abroad","host":"rcseng.ac.uk","quote":"Be wary of surgeons and hospitals that do not want to discuss the details of surgery with you.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F2","text":"An advert or information that guarantees complete success should raise concerns","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F3","text":"Forceful persuasion or cheap, time-limited offers pushing you into a quick decision","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Fevers or flu-like symptoms with a rash","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Contact your care team right away if you notice fevers or flu-like symptoms with a rash.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W2","text":"Allergic reaction to the medicine","urgency":"contact_clinic","general":false,"source":{"url":"https://www.healthline.com/health/drugs/keytruda","host":"healthline.com","quote":"Call your doctor right away if you have an allergic reaction to Keytruda.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W3","text":"Any change in eyesight","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Tell your care team right away if you have any change in your eyesight.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W4","text":"Shortness of breath or trouble breathing","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Dry cough, shortness of breath or trouble breathing.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W5","text":"Chest pain or fast or irregular heartbeat","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/drugs/20941-pembrolizumab-injection","host":"my.clevelandclinic.org","quote":"Heart muscle inflammation—unusual weakness or fatigue, shortness of breath, chest pain, fast or irregular heartbeat.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Gives your home doctor information about your treatment and future care needs","document":"discharge letter for gp","source":{"url":"https://www.nhs.uk/using-the-nhs/nhs-services/hospitals/being-discharged-from-hospital/","host":"nhs.uk","quote":"You'll also be given a letter for your GP, providing information about your treatment and future care needs.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"T2","text":"Ask for copies of all prescriptions before you leave","document":"prescription copies","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Remember to ask for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T3","text":"Home doctor needs the dates for required blood tests and follow-up appointments","document":"written aftercare plan","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"This should include any medication and doses, as well as any dates that blood tests and follow-up appointments must be carried out.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T4","text":"Tells any doctor the patient is on immunotherapy, so side effects are managed correctly","document":"immunotherapy wallet card","source":{"url":"https://www.ons.org/toolkits/immunotherapy-patient-wallet-card-1","host":"ons.org","quote":"The ONS Immunotherapy Patient Wallet Card is intended to communicate with healthcare providers who are not involved with a patient's cancer treatment.","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"alternatives":{"status":"ok","items":[{"id":"A1","text":"Your advanced lung cancer has spread to other body parts","name":"Targeted medicines for lung cancer","source":{"url":"https://www.nhs.uk/conditions/lung-cancer/treatment","host":"nhs.uk","quote":"Targeted medicines or immunotherapy are sometimes used to treat advanced lung cancer that has spread to other parts of the body.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200},"operation_id":null}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"technique_details":{"status":"ok","items":[{"id":"pembrolizumab-monotherapy","name":"Pembrolizumab monotherapy","how_it_works":{"text":"The antibody blocks immune-inhibiting signals, allowing an anti-tumor immune response","source":{"url":"https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/9333c79b-d487-4538-a9f0-71b91a02b287/spl-doc?hl=pembro","host":"nctr-crs.fda.gov","quote":"Pembrolizumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}},{"id":"pembrolizumab-combined","name":"Pembrolizumab combined with chemotherapy","how_it_works":{"text":"The antibody is administered with another cancer treatment to treat cancer","source":{"url":"https://api.fda.gov/drug/label.json?search=openfda.application_number:%22BLA761467%22&limit=1","host":"api.fda.gov","quote":"The most common adverse reactions (≥20%) in patients receiving intravenous pembrolizumab and axitinib were diarrhea, fatigue/asthenia, hypertension, hypothyroidism, decreased appetite, hepatotoxicity, palmar-plantar erythrodysesthesia, nausea, stomatitis/mucosal inflammation, dysphonia, rash, cough, and constipation.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1}}},"techniques":[{"id":"pembrolizumab-monotherapy","name":"Pembrolizumab monotherapy","how_it_works":{"id":"H1","text":"The antibody blocks immune-inhibiting signals, allowing an anti-tumor immune response","source":{"url":"https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/9333c79b-d487-4538-a9f0-71b91a02b287/spl-doc?hl=pembro","host":"nctr-crs.fda.gov","quote":"Pembrolizumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Patients with suitable biomarkers (e.g., high PD-L1, MSI-high) or melanoma","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Outpatient infusion; no downtime in most patients."},{"id":"pembrolizumab-combined","name":"Pembrolizumab combined with chemotherapy","how_it_works":{"id":"H1","text":"The antibody is administered with another cancer treatment to treat cancer","source":{"url":"https://api.fda.gov/drug/label.json?search=openfda.application_number:%22BLA761467%22&limit=1","host":"api.fda.gov","quote":"The most common adverse reactions (≥20%) in patients receiving intravenous pembrolizumab and axitinib were diarrhea, fatigue/asthenia, hypertension, hypothyroidism, decreased appetite, hepatotoxicity, palmar-plantar erythrodysesthesia, nausea, stomatitis/mucosal inflammation, dysphonia, rash, cough, and constipation.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Patients such as those with non-small cell lung cancer or other tumors where the combination is approved","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Added chemotherapy side effects can increase fatigue and recovery time after each cycle."}],"alternatives":{"status":"ok","items":[{"id":"A1","text":"Your advanced lung cancer has spread to other body parts","name":"Targeted medicines for lung cancer","source":{"url":"https://www.nhs.uk/conditions/lung-cancer/treatment","host":"nhs.uk","quote":"Targeted medicines or immunotherapy are sometimes used to treat advanced lung cancer that has spread to other parts of the body.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200},"operation_id":null}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"diagnostic":{"status":"not_applicable"},"country":{"why":{"status":"ok","items":[{"id":"Y1","text":"Turkey's Ministry of Health publishes lists of authorized healthcare providers and facilitators holding authorization certificates","specialties":[],"source":{"url":"https://shgmturizmdb.saglik.gov.tr/EN-69410/announcements.html","host":"shgmturizmdb.saglik.gov.tr","quote":"Updated lists of healthcare providers and facilitators that have been granted authorization certificates by the Ministry","tier":"government","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-05-11","version":1},"travel":{"status":"ok","items":[{"id":"V1","item":"visa","audience":"uk","volatile":true,"text":"UK citizen passport holders can visit Turkey without a visa for up to 90 days in any 180-day period, for business or tourism","source":{"url":"https://www.gov.uk/foreign-travel-advice/turkey/entry-requirements","host":"gov.uk","quote":"You can visit Turkey without a visa for up to 90 days in any 180-day period, for business or tourism.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V2","item":"visa","audience":"us","volatile":true,"text":"US ordinary passport holders are exempt from a visa for up to 90 days in any 180-day period in Turkey","source":{"url":"https://travel.state.gov/content/travel/en/international-travel/International-Travel-Country-Information-Pages/Turkey.html","host":"travel.state.gov","quote":"Ordinary passport holders are exempted from visa up to 90 days in any 180-day period.","tier":"official_travel","fetched_at":"2026-11-11","http_status":403}},{"id":"V3","item":"passport_validity","audience":"uk","volatile":true,"text":"A UK passport must expire at least 150 days after arrival in Turkey and have at least 1 blank page","source":{"url":"https://www.gov.uk/foreign-travel-advice/turkey/entry-requirements","host":"gov.uk","quote":"To enter Turkey, your passport must have an ‘expiry date’ at least 150 days after the date you arrive and at least 1 blank page.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V4","item":"passport_validity","audience":"us","volatile":true,"text":"A US passport must be valid for six months beyond the entry date into Turkey","source":{"url":"https://travel.state.gov/content/travel/en/international-travel/International-Travel-Country-Information-Pages/Turkey.html","host":"travel.state.gov","quote":"Passports must be valid for six months beyond your entry date.","tier":"official_travel","fetched_at":"2026-11-11","http_status":403}},{"id":"V5","item":"prescriptions","audience":"uk","volatile":false,"text":"British prescriptions are not accepted in pharmacies in Turkey","source":{"url":"https://www.gov.uk/foreign-travel-advice/turkey/health","host":"gov.uk","quote":"British prescriptions are not accepted in pharmacies in Turkey.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V6","item":"emergency_number","audience":"all","volatile":false,"text":"Dial 112 and ask for an ambulance in Turkey","source":{"url":"https://www.gov.uk/foreign-travel-advice/turkey/health","host":"gov.uk","quote":"Dial 112 and ask for an ambulance.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2026-12-11","version":1},"other_countries_with_page":["azerbaijan","china","dominican-republic","egypt","germany","india","israel","italy","japan","malaysia","mexico","morocco","republic-of-korea","spain","switzerland","thailand","ukraine","united-states"]},"often_combined_with":{"status":"missing","reason":"not_collected"},"reviews":{"avg_rating":4.59,"count":2822,"scope":"clinic","rating_scale":5,"pros":{"status":"missing","reason":"not_collected"},"cons":{"status":"missing","reason":"not_collected"}},"current":{"seo_text":"<p>Immunotherapy with Keytruda (Pembolizumab) in Turkey typically costs from _op_491_price_from_ to _op_491_price_to_ per treatment cycle. The total investment depends on the required dosage, frequency of infusions, and the specific hospital tier in cities like Istanbul, Ankara, or Gebze. In the US, similar immunotherapy treatments cost around _price_compare_US_average_ on average, and patients in Turkey often save approximately _price_percent_discount_% while receiving care that follows international oncological protocols.</p>\n\n<ul>\n<li><strong>Dosage and frequency:</strong> Costs vary based on 100mg or 200mg doses administered every three to six weeks.</li>\n<li><strong>Diagnostic imaging:</strong> Advanced PET-CT scans or Brain MRIs may add to the base treatment cycle cost.</li>\n<li><strong>Hospital accreditation:</strong> Facilities with JCI accreditation in major hubs like Istanbul typically have higher pricing structures.</li>\n<li><strong>Package inclusions:</strong> Initial consultations, infusion fees, and basic laboratory bloodwork are usually bundled into the price.</li>\n</ul>\n\n<p><strong>Bookimed Expert Insight:</strong> Choosing centers with international affiliations can provide significant value for complex immunotherapy. Anadolu Medical Center follows Johns Hopkins Medicine protocols and offers high-level expertise with ESMO-certified oncologists. For instance, Memorial Şişli was the 21st hospital globally to receive JCI accreditation. Patients can find treatment cycles starting around $2,500 at Medipol Mega or approximately $4,550 at Istanbul Florence Nightingale, ensuring high-tier care at competitive prices.</p>","faq":[{"q":"Is Keytruda (pembrolizumab) available in Turkey?","a":"<p>Keytruda is available in Turkey at JCI-accredited oncology centers in Istanbul and Ankara. Licensed for melanoma, lung, and breast cancers, it follows international European Society for Medical Oncology standards. Top facilities like Anadolu Medical Center maintain strategic collaborations with Johns Hopkins Medicine to provide U.S. protocol-based immunotherapy.</p> <ul> <li><strong>Cost range:</strong> Treatment typically costs _op_491_price_from_ to _op_491_price_to_ per cycle in Turkey.</li> <li><strong>Expert oncologists:</strong> Professors like Yesim Yildirim and Bulent Karagoz have 20+ years of immunotherapy experience.</li> <li><strong>Regulatory approval:</strong> The Turkish Medicines and Medical Devices Agency oversees licensed and off-label applications.</li> <li><strong>Clinical standards:</strong> Hospitals like Istanbul Florence Nightingale hold JCI and ISO certifications for safety.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Anadolu Medical Center stands out because it treats 65,000 patients annually using direct American protocols from Johns Hopkins. While the drug itself is the same globally, this partnership ensures dose calculations and side-effect management mirror U.S. university hospital standards. This high volume of international cases often leads to better-established logistics for sourcing specific vials during global supply fluctuations.</p> <p><strong>Patient Consensus:</strong> Patients report that private Turkish clinics offer significantly faster access to treatment than European public systems. They emphasize bringing all original imaging scans to avoid repeating expensive diagnostic tests upon arrival.</p>"},{"q":"Which are the best hospitals for Keytruda in Turkey?","a":"<p>Turkey's best hospitals for Keytruda are Anadolu Medical Center, Memorial Şişli, and Istanbul Florence Nightingale, which are all Joint Commission International (JCI) accredited. These facilities follow United States oncology protocols through strategic collaborations with institutions like Johns Hopkins Medicine to ensure precise immunotherapy dosing.</p> <ul> <li><strong>Anadolu Medical Center:</strong> Affiliated with Johns Hopkins Medicine, using U.S. protocols for advanced cancer immunotherapy.</li> <li><strong>Memorial Şişli Hospital:</strong> Turkey first JCI-accredited facility, offering personalized treatment through MSI and PD-L1 biomarker testing.</li> <li><strong>Expert oncologists:</strong> Professors like Yesim Yildirim and Necdet Uskent hold European Society for Medical Oncology certifications.</li> <li><strong>Cost savings:</strong> Patients typically save up to _price_percent_discount_% compared to average United States treatment costs.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Anadolu Medical Center stands out because its oncologists follow the same treatment algorithms as Johns Hopkins Hospital in the United States. While many clinics offer Keytruda, Anadolu is one of the few with the Organisation of European Cancer Institutes accreditation. This ensures medication storage and administration meet the highest international safety standards.</p> <p><strong>Patient Consensus:</strong> Patients value the speed of access compared to public options and recommend bringing original scans from home. Reviewers frequently highlight the professionalism of English-speaking coordinators who help navigate complex biomarker testing requirements.</p>"},{"q":"What services are typically included in Turkish treatment packages?","a":"<p>Turkish immunotherapy packages typically include the specific drug dosage, oncologist consultations, and diagnostic monitoring like bloodwork or PET/CT scans. These all-inclusive bundles also manage logistics by providing 4- or 5-star hotel accommodations for 7–14 nights, VIP airport-to-clinic transfers, and dedicated multilingual patient coordinators for seamless communication.</p> <ul> <li><strong>Medical services:</strong> Covers Keytruda infusions, pre-treatment screenings, and specialist consultations with professors.</li> <li><strong>Diagnostic imaging:</strong> Includes essential PET/CT scans and pathology reviews to track treatment response.</li> <li><strong>Logistics:</strong> Provides private VIP transportation between the airport, hotel, and medical center.</li> <li><strong>Hospitality:</strong> Features 7–14 nights in luxury hotels, often allowing a companion at no cost.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> A unique pattern in Turkish oncology is the integration of international protocols, such as Anadolu Medical Center’s strict affiliation with Johns Hopkins Medicine. These packages offer U.S.-standard treatment pathways for _op_491_price_from_, frequently saving patients up to _price_percent_discount_% compared to U.S. costs. Patients should verify if the quoted price covers a single cycle or a multi-infusion protocol before booking.</p> <p><strong>Patient Consensus:</strong> Patients value the transparency of these clinics, noting they focus on necessary medical care without aggressive upselling for unnecessary diagnostic scans. Many appreciate having a dedicated guide to handle all logistics, which reduces stress during complex cancer treatments.</p>"},{"q":"What is the waiting time for treatment?","a":"<p>Wait times for Immunotherapy with Keytruda in Turkey generally range from 1 to 4 weeks. Private Istanbul clinics often initiate treatment within 7 to 14 days. This timeline is significantly faster than the 2-month standard often seen in public healthcare systems for urgent cancer referrals.</p> <ul> <li><strong>Private clinic speed:</strong> Treatment typically begins within 7 to 14 days at top-tier private centers.</li> <li><strong>Public hospital timeline:</strong> Patients in the public sector may wait 1 to 2 months.</li> <li><strong>Documentation impact:</strong> Having completed pathology reports ready can reduce the wait to 1 week.</li> <li><strong>Logistics and supply:</strong> Reliable drug supply chains ensure pembrolizumab availability with minimal bureaucratic delays.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Patients heading to Istanbul often bypass lengthy queues by choosing JCI-accredited centers like Anadolu Medical Center. Their collaboration with Johns Hopkins Medicine allows for rapid diagnostic verification. Data shows that `cash-pay` international patients frequently receive expedited processing. This can shorten the window from the first consultation to the initial infusion by several days.</p> <p><strong>Patient Consensus:</strong> Patients report that private clinics offer a welcoming environment with professional staff who clarify all inquiries immediately. Proactive communication with English-speaking coordinators is essential to confirm drug approval and avoid any potential customs-related scheduling shifts.</p>"},{"q":"Is the medication the same as that used in the US or Europe?","a":"<p>Turkish JCI-accredited oncology centers use the identical Keytruda (pembrolizumab) medication manufactured by Merck, matching the formulation and dosage standards found in the US and Europe. Leading clinics like Anadolu Medical Center maintain direct affiliations with institutions like Johns Hopkins Medicine to ensure international therapeutic protocols.</p> <ul> <li><strong>Manufacturer consistency:</strong> Clinics source original pembrolizumab directly from Merck Sharp and Dohme global supply chains.</li> <li><strong>Regulatory alignment:</strong> Turkish health authorities and the EMA share approximately 90% of drug approval data.</li> <li><strong>Sourcing standards:</strong> Many facilities import medications via EU distributors, ensuring full EMA compliance and safety.</li> <li><strong>Protocol synchronization:</strong> Oncologists align dosing and cycles with ASCO and ESMO international clinical guidelines.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> While the medication is identical, Turkish centers often provide more flexible scheduling for infusion cycles. Research shows centers like Anadolu Medical Center serve 65,000 patients annually using US-based protocols. This high volume allows them to maintain fresh stock of immunotherapy drugs with verified batch numbers directly from the manufacturer.</p> <p><strong>Patient Consensus:</strong> Patients frequently verify batch numbers against global registries to confirm they receive the same branded drug as home. They emphasize that treatment feels seamless because Turkish oncologists match the exact induction cycles used in Western hospitals.</p>"}],"h2":[{"text":"Бұл қалай жұмыс істейді","kind":"content"},{"text":"Түркияда иммунотерапияның кейтрудой (пембролизумаб) бағасы қанша? Қазір біліңіз","kind":"content"},{"text":"Түркияда ең жақсы Иммунотерапия Кейтрудой (Пембролизумаб) клиникаларын ашыңыз: 29 тексерілген опциялар және бағалар","kind":"content"},{"text":"Түркияда иммунотерапияның кейтрудой (пембролизумаб): сапар жоспары","kind":"content"},{"text":"Түркияда иммунотерапияның кейтрудой (пембролизумаб) медициналық бағалауын алыңыз: 30 тәжірибелі дәрігерлер кеңесіңіз","kind":"content"},{"text":"Bookimed науқастарының бейне тарихтары","kind":"content"},{"text":"Bookimed туралы пікірлер: науқастардың нақты тәжірибесімен танысыңыз","kind":"content"},{"text":"Осы контентпен бөлісу","kind":"content"},{"text":"Иммунотерапияда кейтрудой (пембролизумаб) туралы негізгі фактілер","kind":"content"},{"text":"Түркияда иммунотерапияға кейтрудой (пембролизумаб) бойынша ЖҚС","kind":"content"},{"text":"Тегін консультация алу","kind":"content"}]},"placeholders":{"price_from":"{{price_from}}","clinics_count":"{{clinics_count}}","cities_count":"{{cities_count}}","savings_pct":"{{savings_pct}}","data_date":"{{data_date}}"},"legal":{"restricted_markets":{"status":"missing","reason":"not_collected"}},"conflicts":[]}