Dr. Hilmi Apak is a respected pediatric hematology-oncology specialist with more than 21 years of experience. He is trained in pediatric oncology. Dr. Apak has led advanced treatments, including bone marrow transplantation, leukemia chemotherapy, and CAR T-cell therapy.
He has published 75 international medical articles, showing his strong contribution to pediatric oncology research. Dr. Apak has worked as assistant editor for the Turkish Pediatrics Archives Periodical. He has also held important academic and leadership positions, such as Head of Pediatric Hematology-Oncology at Istanbul University-Cerrahpaşa.
General Information and Presentation
He completed his primary education at Şenlikköy Primary School and his secondary education at the Istek Foundation Florya Bilge Kagan High School. He graduated from Istanbul University Cerrahpaşa Faculty of Medicine in 2001. He completed his specialist education in Istanbul Medical Faculty Neurology Department in 2006. In 2006 he worked at the Neurology Clinic and the PharmaZentrum Research Center of the Faculty of Medicine of the University of Basel, Switzerland. Between 2007 and 2011, Bakırköy Prof. Dr. He worked at Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital in the 3rd Neurology Clinic and in the Dementia and Movement Disorders policlinics. Since October 2011, he has been working at Istanbul University of Science, Faculty of Medicine, Neurology, USA.
Experience
İstanbul Bilim University Faculty of Medicine Neurology,
Şişli Florence Nightingale Hospital
Kadıköy Florence Nightingale Hospital Neurology Clinics,
Gayrettepe Metropolitan Florence Nightingale Hospital PET department.
PROFESSIONAL EXPERIENCE
2011-2012
Erzurum Koprukoyu State Hospital
Department: General Medicine
2012-2017
Istanbul University Cerrahpaşa Medical Faculty
Department: Internal Medicine
06/2017-10/2017
Istanbul Gaziosmanpasa Taksim Training and Research Hospital
Department: Internal Medicine
10/2017-11/2018
Istanbul University Istanbul Medical Faculty
Department: Allergy and Immunology Fellowship
2018/2022
Istanbul University Oncology Institute
Department: Medical Oncology Fellowship
2022-2023
Tekirdag City Hospital
Department: Medical Oncology Specialist
2023-present
Istanbul Medipol University Medipol Bahcelievler Private Hospital
Department: Medical Oncology Assoc. Prof.
EDUCATION
2005-2011
Medical Education
Sivas Cumhuriyet University Medical Faculty, Sivas, Turkey
2012-2017
Internal Medicine
Istanbul University Cerrahpaşa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey
2017-2018
Allergy-Immunology Fellowship
Istanbul University Istanbul Medical Faculty
Department of Internal Medicine, Division of Allergy and Immunology, Istanbul, Turkey
2018-2022
Medical Oncology Fellowship
Istanbul University Oncology Institute, Department of Medical Oncology, Istanbul, Turkey
2022
ESMO Board Certification in Medical Oncology
10th September 2022 in Paris, France.
2023
Medical Oncology Assoc. Prof.
Istanbul Medipol University Department of Medical Oncology, Istanbul, Turkey
INTERNATIONAL CLINICAL TRIALS:
1. Astefania - ROCHE
2. PFİZER
3. RECITE - AMGEN
4. NAVIGATE - BAYER
5. RUBY - Tesaro (PRA)
6. ENGOT-ov43/GOG-3036 - MSD
7. ASTRA ZENECA
8. ROSY-O - ASTRA ZENECA
INTERNATIONAL PUBLICATIONS
I. Published journal articles indexed by SCI, SSCI, and AHCI
Weekly Paclitaxel in Classic Kaposi Sarcoma
Carboplatin Desensitization in Ovarian Carcinoma
High-Dose Chemotherapy for Ewing’s Sarcoma
Multidrug Refractory TFE3(+) Renal Cell Carcinoma
Crizotinib Efficacy in NSCLC with MET Alterations
Clinicopathological Features in ALK Mutant NSCLC
PSMA-Based Tumor Burden in Prostate Cancer
Atezolizumab in Metastatic Urothelial Carcinoma
Pulmonary Sarcomatoid Carcinoma
Prognostic Factors in Atezolizumab-Treated Urothelial Carcinoma
Atezolizumab with Chemotherapy in Small Cell Lung Cancer
FOLFIRINOX vs. Gemcitabine + Nab-Paclitaxel in Pancreatic Cancer
Trastuzumab Emtansine in Older HER2-Positive Breast Cancer Patients
Real-Life Efficacy of Osimertinib in Advanced NSCLC
ALK-Positive Cells Percentage and Alectinib Efficacy
Real-World Data on Alectinib in ALK-Positive NSCLC
Prognostic Factors in Metastatic RCC with T790M Mutation
FLOT Regimen in Metastatic Gastric Cancer
Desensitization Protocol in Lenalidomide Hypersensitivity Reactions
Factors Associated with Diagnostic Skin Test Positivity in PPI Hypersensitivity
Efficacy of Capecitabine and Temozolomide in Neuroendocrine Tumors
Subsequent Treatments in Hormone-Positive Breast Cancer Progression
Termination of Trastuzumab in HER2-Positive Metastatic Breast Cancer
Long-term Outcomes and Predictors of Recurrence in Node-Negative Early Stage Breast Cancer
Prognostic Factors Influencing PFS in HER2-Positive Metastatic Breast Cancer
Treatment Efficacy of Ribociclib or Palbociclib plus Letrozole in Metastatic Breast Cancer
Efficacy and Safety of Sorafenib in Adult Metastatic Osteosarcoma Patients
Single-Agent Temozolomide as Salvage Therapy in Heavily Pretreated Metastatic Sarcoma Patients
Outcomes and Prognostic Factors in Metastatic Renal Cell Carcinoma with Brain Metastases
FLOT Regimen in First-Line Treatment of Metastatic Gastric Cancer
Prognostic Factors of Perioperative FLOT Regimen in Operable Gastric Cancer
Efficacy and Outcomes of Systemic Chemotherapy in Posttransplant Kaposi Sarcoma
Comparison of Second-Line Treatments in Metastatic Renal Cell Carcinoma
Toxicity Management and Effectiveness of Regorafenib in Advance GIST Patients: A Real-world Study - Authors: Paksoy, N., Ferhatoğlu, F., Doğan, İ., Khanmammadov, N., Bozbey, H. U., Karabulut, S., & Taştekin, D. - Journal: TURKISH JOURNAL OF ONCOLOGY, 1(1)
Demographic and Clinical Features and Factors Associated with Survival in Patients with Primary Glomerulonephritis: Single Tertiary Center Experience - Authors: Paksoy, N., Trabulus, S., Seyahi, N., & Altiparmak, M. R. - Journal: Namik Kemal Tip Dergisi, 11(1)
Efficacy of Sorafenib in Symptomatic Patients with Pretreated Progressive Desmoid Tumors - Authors: Paksoy, N., Ferhatoglu, F., Dogan, I., Ak, N., Pehlivan, M., Ekenel, M., & Basaran, M.
Nodal Response to Neoadjuvant Chemotherapy is a Better Predictive Factor of Survival Than Miller-Payne Scoring in Breast Cancer - Authors: Ak, Naziye, et al. - Journal: Journal of Oncological Sciences, 7.2: 42-49
Evaluation of Prognostic and Predictive Values of Hemogram Parameters in Patients with Advanced Stage Ovarian Carcinoma - Authors: Ak, Naziye, et al. - Journal: Turkish Journal of Oncology/Türk Onkoloji Dergisi, 2021, 36.4
Identifying Risk Factors Associated with Survival and Drug-Related Toxicities in Imatinib-Resistant Gastrointestinal Stromal Tumor (GIST) Patients Treated with Sunitinib - Authors: Ferhatoglu, F., Karabulut, S., Paksoy, N., & Tastekin, D.
Real-life Outcomes of ROS1 Fusion-positive Metastatic Lung Cancer Patients who were Treated with Crizotinib - Authors: Dogan, İ., Khanmammadov, N., Paksoy, N., Ferhatoglu, F., Aydın, E., Vatansever, S., & Aydine, A. - Journal: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
Predictors of the acquisition of T790M mutation in EGFR-mutant metastatic lung cancer patients who were treated with EGFR inhibitors - Authors: Dogan, I., Khanmammadov, N., Paksoy, N., Vatansever, S., Saip, P., & Aydıner, A. - Journal: Eurasian Journal of Pulmonology
Laterality of Adrenal Gland Metastasis in Lung Cancer: Results of a Comparative Study - Authors: Ferhatoglu, F., Gagatay, T., Okumus, G., Aydiner, A., Paksoy, N., Ak, N., ... & Saip, P. - Journal: Eurasian Journal of Medical Investigation, 7(2)
Poor Risk Factors Affecting Cancer Patients Infected with Covid-19: A Retrospective Comparative Study from a Pandemic Hospital - Authors: Ferhatoglu, F., Kapağan, T., Paksoy, N., Ak, N., Medetalibeyoğlu, A., Şenkal, N., ... & Vatansever, S. - Journal: Turk Onkoloji Dergisi, 38(1)
Systemic Treatment Outcomes of Progressive Medullary Thyroid Carcinoma from the Registries of a Tertiary Cancer Center - Authors: Ferhatoglu, F., Paksoy, N., & Başaran, M. - Journal: Namik Kemal Tip Dergisi, 10(4)
Evaluation of clinical features and risk factors related to late recurrence (> 5 years) in patients with breast cancer - Authors: Ferhatoglu, F., Aydiner, A., & Paksoy, N. - Journal: Journal of Surgery & Medicine (JOSAM), 6(12)
Assessing the Clinical Impact of Lutetium-177 DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) on Metastatic Neuroendocrine Tumors: A Multicenter Real-World Data from Türkiye
Thesis:
Istanbul University Cerrahpaşa Medical Faculty, Internal Medicine Department PAKSOY, Nail. Demographical, clinical characteristics and survival factors in patients withprimary glomerulonephritis: Cerrahpasa Medical Faculty Experience. (2016)
International Refereed Congress / Symposium Publications in Proceedings (ASCO/ESMO Abstracts)
Prognostic factors influencing progression-free survival in HER2 positive metastatic breast cancer patients who treated with lapatinib and capecitabine combination
Efficacy of regorafenib and 5-fluorouracil-based rechallenge treatment in the third-line treatment of metastatic colorectal cancer: A Turkish oncology group study
Long-term outcomes and predictors of recurrence in patients with early-stage node-negative breast cancer
Efficacy of temozolomide in pretreated patients with metastatic sarcoma
Efficacy of sorafenib in symptomatic patients with pretreated progressive desmoid tumors
Efficacy of sorafenib in heavily pretreated adult patients with metastatic osteosarcoma
Outcomes and prognostic factors in metastatic renal cell carcinoma patients with brain metastases
Association of response to first-line chemotherapy with the efficacy of atezolizumab in patients with metastatic urothelial carcinoma
Safety and survival in adult women with platinum-sensitive relapsed BRCA mutant ovarian cancer: A study of patients in Olaparib Turkey Early Access Program—LynTurk study
Atezolizumab in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy: Results of real-life experiences
Experience
2019 – 2019
Insubria University Faculty of Medicine
2015
2013 – 2015
2010 – 2012
2002 – 2003
Education
2010
1992
Prof. Dr. Rafet Eren graduated from Istanbul Faculty of Medicine in 2007. He completed his Internal Medicine specialty training at Marmara University Faculty of Medicine in 2012. In 2018, he became a Hematology subspecialist at Istanbul Training and Research Hospital. In 2019, he was awarded the title of Associate Professor in the field of Hematology. Afterwards, he worked as a faculty member at Başakşehir Çam and Sakura City Hospital, Bozyaka Training and Research Hospital and Istinye University (Istinye University Bahçeşehir and Liv Hospital Vadistanbul) and is currently working at Biruni University Hospital. Dr. Rafet Eren is a member of Turkish Society of Hematology, Hematology Specialty Society and European Society of Hematology and speaks English fluently. He has around 50 publications in national and international refereed journals.
Professional Experience Compulsory Service 2014 - 15 District Health Director - Güroymak Community Health Center/BİTLİS Specialization 2015 - 20 Fırat University Faculty of Medicine, Department of Neurosurgery. Work Location 2024 - present Eskişehir City Hospital Neurosurgery Department Education Siirt Ataturk Anatolian High School 2003 - 07 Fırat University Faculty of Medicine 2007 - 13 SCIENTIFIC ARTICLES • 1. Ozturk S, Erol FS, Akgun B, Surme MB, Artas G, Ozercan IH. Intradural Extramedullary Spinal Cavernous Hemangioma Mimicking Neurofibroma in a Patient Diagnosed with Neurofibromatosis Type I. Turkish Journal of Neurosurgery 2016; 26:141-144. • 2. Akgun B, Ozturk S, Taskent I, Surme MB, Erol FS, Yildirim H. Evaluation of Apparent Diffusion Coefficients in the Cerebellar Tonsils and Bulbus in Chiari Type I Malformations: Comparison Before and After Surgery. Turk Neurosurg. 2017 May 7. • 3. Surme MB, Hergünsel OB, Ertugrul B, Kaplan M. Ossifying Chronic Subdural Hematoma. Turkiye Clinicals Journal of Neurology. 2017;12:44-48 • 4. Akgun B, Surme MB, Ozturk S, Erol FS. Spontaneous Spinal Epidural Hematomas: Evaluation of 12 Cases. F.U. Journal of Health Science and Medicine. 2016; 30:107-111. • 5. Surme MB, Hergunsel OB, Akgun B, Kaplan M. Cranioplasty with preoperatively customized Polymethyl-methacrylate by using 3-Dimensional Printed Polyethylene Terephthalate Glycol Mold. J Neurosci Neurol Disord. 2018; 2:052-064. • 6. Bakal U, Poyraz AK, Tartar T, Akdeniz I, Surme MB, Çelik S. A Rare Complication of Ventriculoperitoneal Shunt: Asymptomatic Small Bowel Perforation Istanbul Med J 2019; 20(6): 571-3. • 7. De Lima L, Surme MB, Gessi M, Mastronuzzi A, Miele E, Tamburrini G, Massimi L. Central nervous system high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)—case-based reviews Child's Nervous System ( 2020) 36:1589–1599 • 8. Surme MB, Demir F, Erol D., Kaplan M. Is There A Genetic Relationship Between Acute Lymphoblastic Leukemia And Meningioma ? A Case Report Of 3 Genes Analyzes. Arq Bras Neurocir 2021;00:1–3. • 9. Gurbuz O, Surme MB. The effect of intradiscal percutaneous radiopaque gel ethanol injection on pain in patients with lumbar disc herniation: Our clinical experience. Eskisehir Med. J. 2022; 3(2):130-137. • 10. Arikan E, Surme MB. Evaluation of Clinical and Radiological Findings of Patients Diagnosed with Spontaneous Intracerebral Hematoma. Mevlana Medical Sciences Journal 2 (2), 70-74. ORAL PRESENTATIONS • Hergünsel OB, Ertugrul B, Surme MB, Kaplan M. A Case of Cervicogenic Headache Treated with C1 Posterior Arch Resection. Turkish Journal of Neurosurgery 30th Scientific Congress, 8-12 April 2016, Antalya. • Ozturk S, Erol FS, Akgun B, Surme MB, Artas G, Ozercan İH. Intradural Extramedullary Spinal Cavernous Hemangioma Mimicking Neurofibroma in a Patient Diagnosed with Neurofibromatosis Type I. Turkish Neurosurgery Society 30th Scientific Congress. 8-12 April 2016, Antalya. • Ertugrul B, Surme MB, Ozturk S, Kaplan M. A Case of Sacrococcygeal Teratoma Presenting with Intergluteal Tail. Turkish Neurosurgery Society 30th Scientific Congress. 8-12 April 2016, Antalya. • Akgun B, Surme MB, Ozturk S, Demir F, Okcesiz I, Erol FS. Evaluation of Acute Lumbar Disc Hernias with Thin Section Lumbar MRI. 12th International Turkish Spine Congress, 19-22 April 2017, Antalya. • Akgun B, Ozturk S, Taskent I, Surme MB, Erol FS, Yildirim H. Evaluation of Apparent Diffusion Coefficients in the Cerebellar Tonsils and Bulbus in Chiari Type I Malformations: Comparison Before and After Surgery. XVI. World Congress of Neurosurgery, August 20-25, 2017, Istanbul. • Akgun B, Surme MB, Ozturk S, Erol FS. Spontaneous Spinal Epidural Hematomas: Evaluation of 12 Cases. 12th International Turkish Spine Congress. 19-22 April 2017, Antalya. • Surme MB, Hergunsel OB, Celik S., Kaplan M, Erol FS. Evaluation of Cases with Cervical Spondylomyelopathy who underwent corpectomy - Our Clinical Experience. Turkish Neurosurgery Society 32nd Scientific Congress. 20-24 April 2018, Antalya. • Surme MB, Hergunsel OB, Akgun B, Kaplan M. Repair of Orbitofrontal Defects Using Polymethylmethacrylate Grafts Created by 3D Printer. Turkish Neurosurgery Society 32nd Scientific Congress. 20-24 April 2018, Antalya. C I T A T I O N S • My publications have a total of 40 citations. CERTIFICATES (OTHER) • 1. I received an Academic Incentive Bonus for 1 year in 2017 for my academic publications. • 2. Community Health Center Physicians Education. 14-18 July 2014, Kars. (Turkish public health institution). • 3. V. Turkey Zoonotic Diseases Symposium. 24 October 2015, Erzurum. (EKMUD- Turkish Infectious Diseases Specialization Association and TVHB - Turkish Veterinary Medical Association). • 4. Meaningful Occupation Solutions Together. 15-17 April 2015, Gothenburg/Sweden. (Lifelong Learning Programme). • 5. Certificate of Achievement (Position: District Health Manager) 2015, Güroymak/ Bitlis • (Güroymak District Governorship) • 6. Between 16.03.2019 - 04.04.2019, I performed my military service in Mamak/Ankara and was given a 'Certificate of Appreciation'. CERTIFICATES (NEUROSURGERY) • 1. Intracranial Aneurysms and Vascular Neuroanatomy. 14-15 January 2017, Mersin (TNDer Neuroanatomy and Neurovascular Education Training Group). • 2. XII. International Turkish Spine Congress. 19-22 April 2017, Antalya (Turkish Spine Association). • 3. Certificate of Use of Experimental Animals. 10.12.2018 – 20.12.2018, Elazig (FÜSEM- Fırat University Continuing Education Center). • 4. Turkish Neurosurgery Academy 4th Scientific Conference. 1-4 November 2018, Adana. • 5. Turkish Neurosurgery Society Training Program 6.Semester 1.Module. 28.06.2018- 01.07.2018, Mudanya/Bursa. (Spinal and Peripheral Nerve Surgery Group). • 6. Turkish Neurosurgery Association Training Program 7.Semester 2.Module 27.06.2019 – 30.06.2019, Van. (Spinal and Peripheral Nerve Surgery Group). • 7. Turkish Neurosurgery Association Training Program 8th Term 1st Course 2-5 May 2019, Kayseri. (Pediatric Neurosurgery Teaching and Training Group). • 8. Current Developments in Gamma Knife Radiosurgery. 30.11.2019, Elazig. (Koç University Faculty of Medicine Prof. Dr. Selçuk Peker) • 9. Turkish Neurosurgery Society 25. Spinal Symposium 28-31 October 2021, Çeşme. (Spinal and Peripheral Nerve Surgery Group) • 10. Turkish Neurosurgery Society, 34. Scientific Congress. September 30 - October 3, 2021, Online • 11. Turkish Neurosurgery Association, NOVA 19-22 May, 2022, Kütahya. (Speaker) • 12. Spinal Deformity Correction Maneuvers Course 21 May 2022, Eskişehir. (Speaker) • 13. Turkish Neurosurgery Society, 35. Scientific Congress. 24 – 27 November 2022, Antalya. (Speaker) • 14. Complex Spinal Surgery, February 4, 2023, Eskişehir (Speaker). • 15. I worked as a fellow in the Pediatric Neurosurgery department of Catholica University (Rome/Italy) Agostino Gemelli Hospital between 15.01.2020 and 14.02.2020 for 1 month. ORAL PRESENTATIONS(2) • Surme MB, Ertugrul B, Sen D, Kaplan M. Is There a Genetic Link Between Meningioma and Acute Lymphoblastic Leukemia? A Case Presentation Involving the Analysis of 3 Genes. 33rd Scientific Congress of the Turkish Neurosurgery Congress. April 11-14, 2019, Antalya. • Ozturk S, Surme MB, Gönen M, Yıldırım H, Korkmaz S, Kocabıçak E. Analysis of Perfusion Changes in White and Grey Matter in Parkinson's Patients Treated with Subthalamic Nucleus Deep Brain Stimulation. 34th Scientific Congress of the Turkish Neurosurgery Congress. September 30 - October 3, 2021, Online." • "Surme MB, Ustun ME. Case of Vertebrobasilar Insufficiency Due to Vertebral Artery Dolichoarteriopathy. NOVA 2022, Kütahya." • "Ustun ME, Surme MB. Can vertebrobasilar insufficiency lead to parkinson like symptoms? EANS 2022, Belgrade." • "Ustun ME, Surme MB. Do vertebral artery stenoses have an atherosclerotic origin? EANS 2022, Belgrade." • "Surme MB, Yilmaz AH, Ustun ME. Could Resistant Urinary Incontinence Be Related to Vertebrobasilar Insufficiency? Our Initial Case Experiences. 31st National Urology Congress. October 27-30, 2022, Cyprus." • "Surme MB, Akgün B, Isci M, Baloglu M, Millet H. Evaluation of the Effectiveness of Surgical Approaches to Cervical Spondylotic Myelopathy on Cervical Spinal Canal Diameter and T2 Signal Intensity. 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya. • Surme MB, Cosar A, Daltaban IS, Ustun ME. Efficacy of a New Surgical Technique for Carotid Artery * "Surme MB, Arikan E, Baloglu M, Millet H, Ercan S. Analysis of Clinical and Radiological Findings in Cases November 24 – 27, 2022, Antalya. • "Surme MB, Cosar A, Ustun ME. Can Vertebrobasilar Insufficiency Cause Parkinson-like Symptoms? 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya. Diagnosed with Spontaneous Intracerebral Hematoma. 35th Scientific Congress of the Turkish Neurosurgery Congress. Dolichoarteriopathies in Patients with Moderate Hemiparesis due to Cerebrovascular Ischemic Attacks. 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya." • "Baloglu M, Millet H, Ercan S, Surme MB, Yayla E. The Effect of MCI-186 on Lipid Peroxidation in Rats with Experimental Traumatic Brain Injury. 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya." * "Surme MB, Ustun ME. Can Quantitative ElectroCorticoGraphy (ECoG) Be More Valuable Than Non -Quantitative ECoG? A Preliminary Report. Bridging Neurosciences and Neurosurgery: New Frontiers in Intraoperative Neurophysiology. February 2 – 4, 2023, Verona, Italy
Neurosurgery Training: Gazi University, Department of Neurosurgery, 2011
H index: 10, I10 Index: 12 Citations: 296
Dr Mehmet Tonge has international and nationwide 32 publications, 12 book chapters, 92 oral and poster presentations and 41 invited lectures, mostly on Stereotactic and Functional Neurosurgery.
Work & Training experience:
2004-2011: Gazi University, Department of Neurosurgery (Residency)
2008: Zurich University Hospital, Department of Neurosurgery (Intraoperative MRI applications), Switzerland
2008: Zurich University Hospital, Department of Neurosurgery: Microneurosurgery, white matter dissection, interventional neuroradiology courses, Switzerland
2011 – 2012: Sinop Ataturk State Hospital, Neurosurgeon
2012 – 2013: Cankiri State Hospital, Neurosurgeon
2013 – 2014: Istanbul Medipol University, Department of Neurosurgery & Gamma Knife Center (Ass Prof)
2013 – now: Maastricht University Neurosurgery & Neuroscience Department (Visiting scientist, PhDc) The Netherlands
2014: Maastricht University, The Netherlands: Deep Brain Stimulation Fellowship 2014-2018: Istanbul Memorial Hospital Neurosurgery: Staff Neurosurgeon
2016-2018: Istanbul Florence Nightingale Hospital (Consultant, Gamma Knife Center)
2018-now: Istanbul Medipol University (Stereotactic & Functional Neurosurgery, Gamma Knife Center) Ass. Prof.)
Dr Mehmet Tonge has completed 4-year cycle EANS (European Association of Neurosurgical Societies) Training courses.
Clinical areas of interest:
• Stereotactic & Functional Neurosurgery
• Surgery for movement disorders
• Gamma Knife Radiosurgery
• Surgery for pain & spasticity
• Psychosurgery
Research areas of interest:
• Deep brain stimulation
• Stereotactic radiosurgery
Administrative duties:
• Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member 2015- 2017
• Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member (Secretary) 2017-2019
• Turkish Skull Base Society: Board member 2016-2018
• Turkish Skull Base Society: Supervisory board member 2018-2020
• Deep Brain Stimulation and Movement Disorders Surgery Society: Executive Board Member, (Accountant) 2023-still
Memberships:
• WSSFN (World Stereotactic & Functional Neurosurgery Society)
• ESSFN (European Stereotactic & Functional Neurosurgery Society)
• Deep Brain Stimulation and Movement Disorders Surgery Society
• Deep Brain Stimulation Society
• International Stereotactic Radiosurgery Society
• Leksell Gamma Knife Society
• EANS (European Association of Neurosurgical Societies)
• Turkish Neurosurgical Society
• Turkish Skull Base Society
Sample Publications:
1. Tonge M. Technological developments in electric based DBS. Deep Brain Stimulation 2024 4(36-41) DOI: https://doi.org/10.1016/j.jdbs.2023.12.001
2. Akgul E, Onan HB, Islek I, Tonge M, Durmus Y, Barburoglu M, Azizova A, Erol C, Hakyemez B, Sencer S, Aydin K, Arat A. Flow diverter stents in the treatment of recanalized intracranial aneurysms. Interv Neuroradiol. 2021 Aug;27(4):481-489. doi: 10.1177/1591019921990507. Epub 2021 Jan 28. PMID: 33509011; PMCID: PMC8580529.
3. Mulders AEP, Temel Y, Tonge M, Schaper FLWVJ, van Kranen-Mastenbroek V,Ackermans L, Kubben P, Janssen MLF, Duits A. The association between surgical characteristics and cognitive decline following deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Clin Neurol Neurosurg. 2021 Jan;200:106341. doi: 10.1016/j.clineuro.2020.106341. Epub 2020 Nov 3. PMID: 33160716.
4. Wetzelaer P, Vlis T, Tonge M, Ackermans L, Kubben P, Evers S, Kocabicak E, Temel Y. Management of Hardware Related Infections after DBS Surgery: A Cost Analysis. Turk Neurosurg. 2018;28(6):929- 933. doi: 10.5137/1019-5149.JTN.21511-17.1. PMID: 29465741.
5. Bedirli N, Emmez G, Ünal Y, Tönge M, Emmez H. Effects of positive end- expiratory pressure on intracranial pressure during pneumoperitoneum and Trendelenburg position in a porcine mode. Turk J Med Sci. 2017 Nov 13;47(5):1610-1615. doi: 10.3906/sag-1609-17. PMID: 29152942.
6. Sari R, Tonge M, Bolukbasi FH, Onoz M, Baskan O, Silav G, Elmaci I. Management of Failed Cranioplasty. Turk Neurosurg. 2017;27(2):201-207. doi: 10.5137/1019-5149.JTN.15395-15.0. PMID: 27593759.
7. Tonge M, Kocabicak E, Ackermans L, Kuijf M, Temel Y. Final Electrode Position in Subthalamic Nucleus Deep Brain Stimulation Surgery: A Comparison of Indirect and Direct Targeting Methods. Turk Neurosurg. 2016;26(6):900-903. doi: 10.5137/1019-5149.JTN.13739-14.1. PMID: 27337232.
8. Tonge M, Ackermans L, Kocabicak E, van Kranen-Mastenbroek V, Kuijf M, Oosterloo M, Kubben P, Temel Y. A detailed analysis of intracerebral hemorrhages in DBS surgeries. Clin Neurol Neurosurg. 2015 Dec;139:183-7. doi: 10.1016/j.clineuro.2015.10.017. Epub 2015 Oct 23. PMID: 26513430.
9. Silav G, Bölükbaşı FH, Özek E, Tönge M, Önöz M, Elmacı İ. A Simple Technique for Bone Storage after Decompressive Craniectomy in Children. Pediatr Neurosurg. 2015;50(3):161-4. doi: 10.1159/000381748. Epub 2015 May 14. PMID: 25998533.
10. Yilmaz MB, Donmez H, Tonge M, Senol S, Tekiner A. Vertebrojugular arteriovenous fistula and pseudoaneurysm formation due to penetrating vertebral artery injury: case report and review of the literature. Turk Neurosurg. 2015;25(1):141-5. doi: 10.5137/1019-5149.JTN.8247-13.1. PMID: 25640560.
11. Kurt G, Tönge M, Çeltıkçı E, Çapraz I, Serdaroğlu A, Bılır E. Surgery for intractable temporal lobe epilepsy: experience of a single institution. Turk J Med Sci. 2014;44(5):866-70. doi: 10.3906/sag-1307- 30. PMID: 25539559.
12. Yılmaz MB, Tönge M, Emmez H, Kaymaz F, Kaymaz M. Neuroprotective effects of quetiapine on neuronal apoptosis following experimental transient focal cerebral ischemia in rats. J Korean Neurosurg Soc. 2013 Jul;54(1):1-7. doi: 10.3340/jkns.2013.54.1.1. Epub 2013 Jul 31. PMID: 24044072; PMCID: PMC3772279.
13. Yilmaz MB, Egemen E, Tonge M, Kaymaz M. Transoral protrusion of a peritoneal catheter due to gastric perforation 10 years after a ventriculoperitoneal shunting: case report and review of the literature. Turk Neurosurg. 2013;23(2):285-8. doi: 10.5137/1019-5149.JTN.4904-11.1. PMID: 23546921.
14. Omerhodzic I, Tonge M, Matos B, Musabeliu E, Raspanti C, Ferdinandov D, Galimova R, Muroi C, Balik V, Kursumovic A. Neurosurgical training programme in selected European countries: from the young neurosurgeons' point of view. Turk Neurosurg. 2012;22(3):286-93. doi: 10.5137/1019- 5149.JTN.5133-11.0. PMID: 22664994.
15. Ergun E, Kurt G, Tonge M, Aytar H, Tas M, Baykaner K, Ceviker N. Effects of phenytoin sodium on dura mater healing in a rat model of CSF leakage. Turk Neurosurg. 2011;21(4):471-6. PMID: 22194102.
16. Emmez H, Tonge M, Tokgoz N, Durdag E, Gonul I, Cevıker N. Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety. Turk Neurosurg. 2010 Oct;20(4):485-91. doi: 10.5137/1019- 5149.JTN.3300-10.2. PMID: 20963698.
17. Emmez H, Yildirim Z, Kale A, Tönge M, Durdağ E, Börcek AO, Uçankuş LN, Doğulu F, Kiliç N, Baykaner MK. Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemiareperfusion injury in rabbits. Acta Neurochir (Wien). 2010 Sep;152(9):1591-600; discussion 1600-1. doi: 10.1007/s00701-010-0703-9. Epub 2010 Jun 10. PMID: 20535507.
18. Kurt G, Tonge M, Börcek AO, Karahacioglu E, Gurel O, Baykaner K, Ceviker N, Aykol S. Fractionated gamma knife radiosurgery for optic nerve tumors: a technical report. Turk Neurosurg. 2010 Apr;20(2):241-6. doi: 10.5137/1019-5149.JTN.1681-09.3. PMID: 20401852.
19. Emmez H, Kale A, Tönge M, Cakir A, Ceviker N. Two meningiomas with different histological grades in the same patient. Case report. Neurol Med Chir (Tokyo). 2010;50(8):686-8. doi: 10.2176/nmc.50.686. PMID: 20805656.
1- SSI Тепеджик Ауруханасының Балалар Онкологиясы Клиникасы (1990)
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Халықаралық журналдарда үлкен саны басылып шыққан зерттеулер мен мақалаларға қоса, ол жоғары әсерлі факторлы кейбір журналдарда халықаралық көпорталықты зерттеулерге қатысады.
Prof. Erkan Kaptanoğlu, M.D. was born in Balikesir, Turkey in 1966. After completing his primary school, secondary school and high school education in Balikesir, he graduated from Istanbul University, Cerrahpasa Faculty of Medicine in 1990. He completed his internship at Peterborough District Hospital and Lincoln County Hospital in the United Kingdom. After a year of compulsory medical service, he completed his residency, which he had started in 1992, at Ankara Numune Training and Research Hospital in 1997 and became a Neurosurgery Specialist. After being assigned at the same hospital as Chief Resident in the same year, he studied “spinal cord injury and spinal cord regeneration” as a “research fellow” alongside Prof. Charles Tator, M.D., at the University of Toronto Faculty of Medicine in 1998-1999. After returning from Canada in 1999, he was tasked by the Ministry of Health to establish a Field Hospital and to work in cooperation with the Turkish Red Crescent Society at Hakkari, Şemdinli for two months. Following this assignment, he volunteered to work for the 1999 Marmara Earthquake relief effort.
He became an Associate Professor of Neurosurgery in 2004. He earned the title Doctor of Science (Ph.D.) by completing a doctorate program on Advanced Neuroscience between 2000-2005, at Hacettepe University Institute of Medical Sciences. He joined the project for autologous stem cell therapy in human spinal cord injuries with the Departments of Neurosurgery and Hematology at the Ankara University Faculty of Medicine. In 2009, he was appointed as Deputy Chief to the 1st Neurosurgery Clinic at the Ankara Numune Hospital, where he had been working.
At this hospital, in which he worked until 2010, he supervised and attended complex cranial, pediatric, spinal, trauma and vascular neurosurgery operations. He continued his academic research at Ankara University, Department of Anatomy and research laboratories of Ankara University and Hacettepe University for the purpose of developing strategies for complex spinal surgery operations.
With his research on spinal cord injuries and spinal anatomy, he won many awards such as the Acibadem Hospital Medical Research Award, 1st Place in 2000, Turkish Neurosurgical Society Dr. Mahir Tevruz Scientific Research Award, Tübitak and Brain Research Society Wheyt Award in 2001, Turkish Neurosurgical Society Hamit Ziya Gokalp Young Neurosurgeons Research Award, 2nd Place in 2002, Turkish Neurosurgical Society Yildiz Yalcinlar Scientific Research Award in 2004.
In 2010, he went to Cyprus to found the Near East University Faculty of Medicine Hospital with the guidance of Hacettepe University, and was appointed as full Professor. Between 2010-2015, he served as the Founder and Head of Department at the Near East University and Founder and Deputy Chief Physician at the University Training and Research Hospital in TRNC.
In 2000-2001, he served as a member of the editorial board for Türk Nöroşirurji Dergisi and Turkish Neurosurgery journal. Between the years 2001-2006, he served as an assistant editor for Türk Nöroşirurji Dergisi and Turkish Neurosurgery journals. In 2002-2003, he served as the Chairman of the Young Neurosurgeons Committee under the Turkish Neurosurgical Society. He was elected to the Turkish Neurosurgical Society Spinal and Peripheral Nerve Surgery Group Board of Directors to serve between 2003-2009. In 2013, he was again elected as a member to the Turkish Neurosurgical Society Spinal and Peripheral Nerve Surgery Group Board of Directors. In 2015, he became the Chairman of the Turkish Neurosurgical Society Spinal and Peripheral Nerve Surgery Group Board of Directors. In 2018, he was elected as a member to the Board of Turkish Neurosurgery Academy.
In 2015, he was appointed to the Marmara University Faculty of Medicine, Department of Neurosurgery and was elected as the Head of Department. During the same period, he also served as the Director of the Institute of Neuroscience. In 2018, he completed his tenure as the Head of Department. Reaching the end of this tenure in 2019, he retired from his duties as the Director of the Institute of Neuroscience and as a Member of the Faculty of Medicine. During his tenure at Marmara University, he supervised and accompanied surgical operations for complex cases from cranial patients to brain tumors (gliomas, meningiomas and hypophysis adenomas in particular), cerebral hemorrhages, Parkinson’s disease, trauma and vascular neurosurgery. He performed complex spinal surgery operations such as surgeries for spinal deformities (e.g. scoliosis and kyphosis), thoracoscopic spinal surgeries and sacral tumor surgeries. He conducted research and experimental studies on stem cell therapy and regeneration in spinal cord injuries. Between 2019-2020, currently He continues his clinical practice and surgeries along with his local and international academic studies, from his private clinic and Istanbul Brain and Spine Center.
He has attended numerous national and international courses and meetings as an instructor and speaker, was a guest speaker in over 100 events and conferences. He has published 65 international, 35 national scientific articles, edited 7 books, written 52 book chapters. He has served in the organizational committee 5 times in international meetings and 22 times in national meetings.
He is a member of the Turkish Medical Association, Turkish Cypriot Medical Association, Turkish Neurosurgical Society, Turkish Spine Society, EUROSPINE, AO Spine, Turkish Neurosurgery Academy.
Портфолиоды қарау
Work and Interest Areas
Education
Experience
Memberships in Scientific Organizations
Medical Area of Interest and Activities
Functional Neurosurgery (Parkinson’s, Deep Brain Stimulation)
Brain and Spinal tumors
Spinal degenerative diseases Education
Istanbul University Cerrahpaşa Faculty of Medicine
Trakya University Faculty of Medicine Brain and Nerve Surgery
Education
Istanbul University Cerrahpaşa Faculty of Medicine
Trakya University Faculty of Medicine Brain and Nerve Surgery
Experience
Ankara Gülhane Military Medical Academy Brain and Nerve Surgery
Osmaniye State Hospital
Bolu State Hospital
Private Taksim German Hospital
Taksim Training and Research Hospital
Istanbul University Faculty of Medicine Brain and Nerve Surgery
Liv Hospital Ulus
Memberships
Turkish Neurosurgery Society
Turkish Medical Association
Research and Publications
Development of micro-neurosurgery laboratory training model for orbita and optical nerves on fresh lamb cadaver (2007) •
Effect of Astaxanthin on NMDA sub units and MRNA expression levels in Primary Cortical Neurons
Articles in International Journals (18)
Chapters in International Books (1)
Articles in National Journals (5)
International Papers (12)
National Papers (24)
uzmanlık
Specializations
Abdomen Radiology
Doppler Radiology
Obstetric Radiology
Breast Radiology
Musculoskeletal Radiology
Pediatric Radiology
Neuroradiology
Nonvascular Interventional Procedures
Experience
Liman Hospital Radiology Clinic
Academy Medical Center
Anaclinic Medical Center
Kayseri State Hospital
Kayseri Erciyes University Radiology Clinic
Samsun Private Midiliv Medical Center
Samsun Büyük Anadolu Hospital (2023)
KTU Faculty of Medicine 2005-2011
Izmir Ege University Faculty of Medicine Hospital Department of Brain and Nerve Surgery
2011-2017 Erzincan BY University Faculty of Medicine
2017-2023 Izmir University of Economics Medicalpark Hospital
AREAS OF INTEREST AND TREATMENT METHODS USED;
Spine Surgery
Lumbar hernias, (fully closed herniated disc surgery, microsurgery herniated disc surgery)
Cervical hernias (fully closed cervical disc herniation surgery, microsurgery cervical disc herniation surgery)
Spinal Fracture Treatment (open surgery and fully closed surgery = kyphoplasty vertebroplasty)
Scoliosis (Spine Curvatures)
Ankylosing Spondylitis (Hunchback)
Spine Tumors
Nerve Compression
Endoscopic (Closed Method) Brain Tumor Surgeries
Brain tumor surgery with neuronavigation
Brain Hemorrhages
Pain Intervention Procedures (Radiofrequency, Laser)
Hydrocephalus (accumulation of water in the brain)
Congenital Anomalies
Minimally Invasive Procedures and Head Traumas.
Білім және мамандану:
Кәсіби тәжірибе:
Мамандану салалары:
Ғылыми зерттеулер және жарияланымдар: Проф. Др. Арсланның ми және омыртқа ісіктерін емдеу, инновациялық нейрохирургиялық техникасы және нейрохирургиялық араласудың нәтижелері туралы көптеген басылымдары бар. Оның жұмысына мидың ишемия/реперфузиялық зақымдалысы, омыртқа ишемиясы және басқа да нейрохирургиялық жағдайлар бойынша зерттеулер кіреді.
Кәсіби мүшеліктер:
Parkinson's Disease Diagnosis and Treatments
Alzheimer's Diagnosis and Treatments
Epilepsy (Epileptic)
EEG and Treatment
Muscle and Nerve Disease Diagnosis and Treatments
Vertigo Diagnosis and Treatment
Restless Leg Syndrome
Stroke (Cerebral Palsy) Diagnosis and Treatment
Bartın State Hospital (2007-2009)
VM Medical Park Samsun Hospital (2009-2017)
VM Medical Park Samsun Hospital - Deputy Chief Physician (2019-2021)
Samsun Education and Research Hospital (2021-2022)
Çarşamba State Hospital
Private Atasam Samsun Hospital (2022-2024)
Karadeniz Technical University (1989-1995)
Ondokuz Mayis University Faculty of Medicine (2001-2006)
Op. Dr. Kemal Paksoy was born in Trabzon in 1982. In 2007, he graduated from Karadeniz Technical University Faculty of Medicine. In 2014, he completed his specialty training at Ondokuz Mayıs University Faculty of Medicine, Department of Neurosurgery. Between 2014-2018, he worked at Rize Kaçkar State Hospital Neurosurgery Clinic. Between 2018 and 2024, he worked at Memorial Hospitals Group Spine Center. Since 2023, he has been a member of the academic staff as Dr. Faculty Member at Üsküdar University Faculty of Medicine. Since 2024, he has been working at NPISTANBUL Brain Hospital Neurosurgery Clinic.
Dr. Kemal Paksoy has also worked in many clinics in the fields of neuromodulation and algology and has participated as a participant, speaker and organizer in dozens of scientific meetings held in Turkey and abroad.
He has published in many international and national scientific journals.